Tetratricopeptide repeat protein 9B (TTC9B)
Homo sapiens — UniProt Q8N6N2
Data last refreshed: (UniProt release unknown)
Key facts
Tetratricopeptide repeat protein 9B (TTC9B) is a protein from Homo sapiens identified by UniProt accession Q8N6N2, 239 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q8N6N2; gene symbol TTC9B.
- Organism: Homo sapiens.
- Length: 239 amino acids.
- Top disease associations (Open Targets): C-reactive protein measurement, alkaline phosphatase measurement and birth weight.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tetratricopeptide repeat protein 9B |
|---|---|
| UniProt accession | Q8N6N2 |
| Gene | TTC9B |
| Organism | Homo sapiens |
| Length | 239 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- C-reactive protein measurement · score 0.16
- alkaline phosphatase measurement · score 0.07
- birth weight · score 0.07
- creatinine measurement · score 0.06
- mean corpuscular volume · score 0.05
- nicotine metabolite ratio · score 0.05
- atypical teratoid rhabdoid tumor · score 0.03
- resting heart rate · score 0.03
- glioblastoma multiforme · score 0.02
- ependymoma · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6N2-F1 | alphafold | PREDICTED | 75.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6N2.
Amino-acid sequence (239 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TTC9B?
The strongest Open Targets associations for TTC9B are C-reactive protein measurement, alkaline phosphatase measurement, birth weight, creatinine measurement and mean corpuscular volume.
How long is the TTC9B protein?
The Homo sapiens TTC9B protein (UniProt Q8N6N2) is 239 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6N2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6N2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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