Interleukin-22 receptor subunit alpha-1 (IL22RA1)
Homo sapiens — UniProt Q8N6P7
Data last refreshed: (UniProt release unknown)
Key facts
Interleukin-22 receptor subunit alpha-1 (IL22RA1) is a protein from Homo sapiens identified by UniProt accession Q8N6P7, 574 residues long. MolForge cross-references it against 0 known binders and 205 disease associations.
- UniProt accession: Q8N6P7; gene symbol IL22RA1.
- Organism: Homo sapiens.
- Length: 574 amino acids.
- Top disease associations (Open Targets): C-reactive protein measurement, COVID-19 and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interleukin-22 receptor subunit alpha-1 |
|---|---|
| UniProt accession | Q8N6P7 |
| Gene | IL22RA1 |
| Organism | Homo sapiens |
| Length | 574 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (205)
Diseases linked to this target (Open Targets).
- C-reactive protein measurement · score 0.32
- COVID-19 · score 0.11
- cancer · score 0.08
- plasma fibronectin deficiency · score 0.06
- glioblastoma multiforme · score 0.06
- Crigler-Najjar syndrome type 2 · score 0.06
- Miyoshi myopathy · score 0.05
- metabolite measurement · score 0.05
- transient familial neonatal hyperbilirubinemia · score 0.04
- congenital enteropathy due to enteropeptidase deficiency · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6P7-F1 | alphafold | PREDICTED | 61.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6P7.
Amino-acid sequence (574 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IL22RA1?
The strongest Open Targets associations for IL22RA1 are C-reactive protein measurement, COVID-19, cancer, plasma fibronectin deficiency and glioblastoma multiforme.
How long is the IL22RA1 protein?
The Homo sapiens IL22RA1 protein (UniProt Q8N6P7) is 574 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6P7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6P7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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