Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A)
Homo sapiens — UniProt Q8N6Q1
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane and coiled-coil domain-containing protein 5A (TMCO5A) is a protein from Homo sapiens identified by UniProt accession Q8N6Q1, 288 residues long. MolForge cross-references it against 0 known binders and 72 disease associations.
- UniProt accession: Q8N6Q1; gene symbol TMCO5A.
- Organism: Homo sapiens.
- Length: 288 amino acids.
- Top disease associations (Open Targets): diet measurement, forced expiratory volume and FEV/FVC ratio.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane and coiled-coil domain-containing protein 5A |
|---|---|
| UniProt accession | Q8N6Q1 |
| Gene | TMCO5A |
| Organism | Homo sapiens |
| Length | 288 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (72)
Diseases linked to this target (Open Targets).
- diet measurement · score 0.25
- forced expiratory volume · score 0.24
- FEV/FVC ratio · score 0.24
- femoral neck bone mineral density · score 0.23
- bone density · score 0.23
- appendicular lean mass · score 0.22
- retinal vascular disorder · score 0.21
- retinopathy · score 0.21
- body height · score 0.20
- gut microbiome measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6Q1-F1 | alphafold | PREDICTED | 84.66 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6Q1.
Amino-acid sequence (288 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMCO5A?
The strongest Open Targets associations for TMCO5A are diet measurement, forced expiratory volume, FEV/FVC ratio, femoral neck bone mineral density and bone density.
How long is the TMCO5A protein?
The Homo sapiens TMCO5A protein (UniProt Q8N6Q1) is 288 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6Q1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6Q1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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