CD177 antigen (CD177)
Homo sapiens — UniProt Q8N6Q3
Data last refreshed: (UniProt release unknown)
Key facts
CD177 antigen (CD177) is a protein from Homo sapiens identified by UniProt accession Q8N6Q3, 437 residues long. MolForge cross-references it against 0 known binders and 543 disease associations.
- UniProt accession: Q8N6Q3; gene symbol CD177.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, blood protein measurement and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | CD177 antigen |
|---|---|
| UniProt accession | Q8N6Q3 |
| Gene | CD177 |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (543)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- blood protein measurement · score 0.30
- eosinophil count · score 0.30
- glioblastoma multiforme · score 0.25
- lung adenocarcinoma · score 0.25
- squamous cell lung carcinoma · score 0.19
- cutaneous melanoma · score 0.18
- head and neck squamous cell carcinoma · score 0.17
- neoplasm · score 0.11
- cancer · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6Q3-F1 | alphafold | PREDICTED | 85.22 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6Q3.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CD177?
The strongest Open Targets associations for CD177 are neurodegenerative disease, blood protein measurement, eosinophil count, glioblastoma multiforme and lung adenocarcinoma.
How long is the CD177 protein?
The Homo sapiens CD177 protein (UniProt Q8N6Q3) is 437 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6Q3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6Q3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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