Probable methyltransferase-like protein 25 (METTL25)
Homo sapiens — UniProt Q8N6Q8
Data last refreshed: (UniProt release unknown)
Key facts
Probable methyltransferase-like protein 25 (METTL25) is a protein from Homo sapiens identified by UniProt accession Q8N6Q8, 603 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: Q8N6Q8; gene symbol METTL25.
- Organism: Homo sapiens.
- Length: 603 amino acids.
- Top disease associations (Open Targets): protein measurement, adolescent idiopathic scoliosis and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable methyltransferase-like protein 25 |
|---|---|
| UniProt accession | Q8N6Q8 |
| Gene | METTL25 |
| Organism | Homo sapiens |
| Length | 603 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.38
- adolescent idiopathic scoliosis · score 0.24
- body mass index · score 0.18
- diet measurement · score 0.08
- neuroticism measurement · score 0.04
- body weight · score 0.04
- hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.04
- thrombocytopenia, anemia, and myelofibrosis · score 0.04
- glycoprotein storage disease · score 0.03
- Tyrosinemia type 1 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6Q8-F1 | alphafold | PREDICTED | 76.56 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6Q8.
Amino-acid sequence (603 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL25?
The strongest Open Targets associations for METTL25 are protein measurement, adolescent idiopathic scoliosis, body mass index, diet measurement and neuroticism measurement.
How long is the METTL25 protein?
The Homo sapiens METTL25 protein (UniProt Q8N6Q8) is 603 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6Q8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6Q8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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