eEF1A lysine and N-terminal methyltransferase (METTL13)
Homo sapiens — UniProt Q8N6R0
Data last refreshed: (UniProt release unknown)
Key facts
eEF1A lysine and N-terminal methyltransferase (METTL13) is a protein from Homo sapiens identified by UniProt accession Q8N6R0, 699 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.
- UniProt accession: Q8N6R0; gene symbol METTL13.
- Organism: Homo sapiens.
- Length: 699 amino acids.
- Top disease associations (Open Targets): mean platelet volume, platelet component distribution width and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | eEF1A lysine and N-terminal methyltransferase |
|---|---|
| UniProt accession | Q8N6R0 |
| Gene | METTL13 |
| Organism | Homo sapiens |
| Length | 699 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (142)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.40
- platelet component distribution width · score 0.33
- platelet count · score 0.30
- blood protein measurement · score 0.30
- glaucoma · score 0.25
- intelligence · score 0.25
- open-angle glaucoma · score 0.23
- Juvenile glaucoma · score 0.17
- azoospermia · score 0.09
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6R0-F1 | alphafold | PREDICTED | 87.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6R0.
Amino-acid sequence (699 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with METTL13?
The strongest Open Targets associations for METTL13 are mean platelet volume, platelet component distribution width, platelet count, blood protein measurement and glaucoma.
How long is the METTL13 protein?
The Homo sapiens METTL13 protein (UniProt Q8N6R0) is 699 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6R0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6R0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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