Stress-associated endoplasmic reticulum protein 2 (SERP2)
Homo sapiens — UniProt Q8N6R1
Data last refreshed: (UniProt release unknown)
Key facts
Stress-associated endoplasmic reticulum protein 2 (SERP2) is a protein from Homo sapiens identified by UniProt accession Q8N6R1, 65 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q8N6R1; gene symbol SERP2.
- Organism: Homo sapiens.
- Length: 65 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, cortical thickness and sex hormone-binding globulin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Stress-associated endoplasmic reticulum protein 2 |
|---|---|
| UniProt accession | Q8N6R1 |
| Gene | SERP2 |
| Organism | Homo sapiens |
| Length | 65 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.36
- cortical thickness · score 0.34
- sex hormone-binding globulin measurement · score 0.29
- peripheral arterial disease · score 0.27
- traffic air pollution measurement · score 0.27
- brain measurement · score 0.27
- chronic obstructive pulmonary disease · score 0.26
- Dupuytren Contracture · score 0.26
- body height · score 0.22
- FEV/FVC ratio · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6R1-F1 | alphafold | PREDICTED | 80.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6R1.
Amino-acid sequence (65 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SERP2?
The strongest Open Targets associations for SERP2 are heel bone mineral density, cortical thickness, sex hormone-binding globulin measurement, peripheral arterial disease and traffic air pollution measurement.
How long is the SERP2 protein?
The Homo sapiens SERP2 protein (UniProt Q8N6R1) is 65 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6R1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6R1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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