ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)
Homo sapiens — UniProt Q8N6T3
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) is a protein from Homo sapiens identified by UniProt accession Q8N6T3, 406 residues long. MolForge cross-references it against 0 known binders and 3 disease associations.
- UniProt accession: Q8N6T3; gene symbol ARFGAP1.
- Organism: Homo sapiens.
- Length: 406 amino acids.
- Top disease associations (Open Targets): breast adenocarcinoma, basal ganglia disease and neuroticism measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylation factor GTPase-activating protein 1 |
|---|---|
| UniProt accession | Q8N6T3 |
| Gene | ARFGAP1 |
| Organism | Homo sapiens |
| Length | 406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (3)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.10
- basal ganglia disease · score 0.09
- neuroticism measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6T3-F1 | alphafold | PREDICTED | 60.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6T3.
Amino-acid sequence (406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARFGAP1?
The strongest Open Targets associations for ARFGAP1 are breast adenocarcinoma, basal ganglia disease and neuroticism measurement.
How long is the ARFGAP1 protein?
The Homo sapiens ARFGAP1 protein (UniProt Q8N6T3) is 406 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6T3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6T3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.