G-protein coupled receptor 161 (GPR161)
Homo sapiens — UniProt Q8N6U8
Data last refreshed: (UniProt release unknown)
Key facts
G-protein coupled receptor 161 (GPR161) is a protein from Homo sapiens identified by UniProt accession Q8N6U8, 529 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q8N6U8; gene symbol GPR161.
- Organism: Homo sapiens.
- Length: 529 amino acids.
- Top disease associations (Open Targets): medulloblastoma, pituitary stalk interruption syndrome and Red cell distribution width.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | G-protein coupled receptor 161 |
|---|---|
| UniProt accession | Q8N6U8 |
| Gene | GPR161 |
| Organism | Homo sapiens |
| Length | 529 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- medulloblastoma · score 0.60
- pituitary stalk interruption syndrome · score 0.44
- Red cell distribution width · score 0.36
- HbA1c measurement · score 0.32
- mean corpuscular volume · score 0.21
- hair colour measurement · score 0.17
- protein measurement · score 0.16
- sex hormone-binding globulin measurement · score 0.14
- hemoglobin A1 measurement · score 0.07
- isolated spina bifida · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6U8-F1 | alphafold | PREDICTED | 68.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6U8.
Amino-acid sequence (529 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GPR161?
The strongest Open Targets associations for GPR161 are medulloblastoma, pituitary stalk interruption syndrome, Red cell distribution width, HbA1c measurement and mean corpuscular volume.
How long is the GPR161 protein?
The Homo sapiens GPR161 protein (UniProt Q8N6U8) is 529 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6U8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6U8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.