Leucine-rich repeat-containing protein 17 (LRRC17)
Homo sapiens — UniProt Q8N6Y2
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat-containing protein 17 (LRRC17) is a protein from Homo sapiens identified by UniProt accession Q8N6Y2, 441 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q8N6Y2; gene symbol LRRC17.
- Organism: Homo sapiens.
- Length: 441 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean arterial pressure and response to cold pressor test.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat-containing protein 17 |
|---|---|
| UniProt accession | Q8N6Y2 |
| Gene | LRRC17 |
| Organism | Homo sapiens |
| Length | 441 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.20
- mean arterial pressure · score 0.12
- response to cold pressor test · score 0.12
- cortical thickness · score 0.11
- cortical surface area measurement · score 0.11
- chronotype measurement · score 0.10
- diverticular disease · score 0.09
- type 2 diabetes mellitus · score 0.09
- brain measurement · score 0.09
- circadian rhythm · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N6Y2-F1 | alphafold | PREDICTED | 78.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N6Y2.
Amino-acid sequence (441 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRRC17?
The strongest Open Targets associations for LRRC17 are neurodegenerative disease, mean arterial pressure, response to cold pressor test, cortical thickness and cortical surface area measurement.
How long is the LRRC17 protein?
The Homo sapiens LRRC17 protein (UniProt Q8N6Y2) is 441 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N6Y2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N6Y2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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