About ER membrane protein complex subunit 1
ER membrane protein complex subunit 1 (EMC1) is a protein
from Homo sapiens identified by UniProt accession
Q8N766, 993 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | ER membrane protein complex subunit 1 |
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| UniProt accession | Q8N766 |
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| Gene | EMC1 |
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| Organism | Homo sapiens |
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| Length | 993 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- cerebellar atrophy, visual impairment, and psychomotor retardation; · score 0.73
- hypotonia, infantile, with psychomotor retardation and characteristic facies · score 0.53
- genetic disorder · score 0.47
- Global developmental delay · score 0.41
- Cerebellar atrophy · score 0.41
- Retinal dystrophy · score 0.38
- global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome · score 0.37
- autosomal recessive retinitis pigmentosa · score 0.33
- congenital hydronephrosis · score 0.27
- congenital anomaly of kidney and urinary tract · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q8N766-F1 | alphafold | PREDICTED | 87.43 | — |
Amino-acid sequence (993 residues)
MAAEWASRFW LWATLLIPAA AVYEDQVGKF DWRQQYVGKV KFASLEFSPG SKKLVVATEK NVIAALNSRT GEILWRHVDK GTAEGAVDAM LLHGQDVITV SNGGRIMRSW ETNIGGLNWE ITLDSGSFQA LGLVGLQESV RYIAVLKKTT LALHHLSSGH LKWVEHLPES DSIHYQMVYS YGSGVVWALG VVPFSHVNIV KFNVEDGEIV QQVRVSTPWL QHLSGACGVV DEAVLVCPDP SSRSLQTLAL ETEWELRQIP LQSLDLEFGS GFQPRVLPTQ PNPVDASRAQ FFLHLSPSHY ALLQYHYGTL SLLKNFPQTA LVSFATTGEK TVAAVMACRN EVQKSSSSED GSMGSFSEKS SSKDSLACFN QTYTINLYLV ETGRRLLDTT ITFSLEQSGT RPERLYIQVF LKKDDSVGYR ALVQTEDHLL LFLQQLAGKV VLWSREESLA EVVCLEMVDL PLTGAQAELE GEFGKKADGL LGMFLKRLSS QLILLQAWTS HLWKMFYDAR KPRSQIKNEI NIDTLARDEF NLQKMMVMVT ASGKLFGIES SSGTILWKQY LPNVKPDSSF KLMVQRTTAH FPHPPQCTLL VKDKESGMSS LYVFNPIFGK WSQVAPPVLK RPILQSLLLP VMDQDYAKVL LLIDDEYKVT AFPATRNVLR QLHELAPSIF FYLVDAEQGR LCGYRLRKDL TTELSWELTI PPEVQRIVKV KGKRSSEHVH SQGRVMGDRS VLYKSLNPNL LAVVTESTDA HHERTFIGIF LIDGVTGRII HSSVQKKAKG PVHIVHSENW VVYQYWNTKA RRNEFTVLEL YEGTEQYNAT AFSSLDRPQL PQVLQQSYIF PSSISAMEAT ITERGITSRH LLIGLPSGAI LSLPKALLDP RRPEIPTEQS REENLIPYSP DVQIHAERFI NYNQTVSRMR GIYTAPSGLE STCLVVAYGL DIYQTRVYPS KQFDVLKDDY DYVLISSVLF GLVFATMITK RLAQVKLLNR AWR
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