ER membrane protein complex subunit 1 (EMC1)
Homo sapiens — UniProt Q8N766
Data last refreshed: (UniProt release unknown)
Key facts
ER membrane protein complex subunit 1 (EMC1) is a protein from Homo sapiens identified by UniProt accession Q8N766, 993 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8N766; gene symbol EMC1.
- Organism: Homo sapiens.
- Length: 993 amino acids.
- Top disease associations (Open Targets): cerebellar atrophy, visual impairment, and psychomotor retardation;, hypotonia, infantile, with psychomotor retardation and characteristic facies and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ER membrane protein complex subunit 1 |
|---|---|
| UniProt accession | Q8N766 |
| Gene | EMC1 |
| Organism | Homo sapiens |
| Length | 993 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- cerebellar atrophy, visual impairment, and psychomotor retardation; · score 0.73
- hypotonia, infantile, with psychomotor retardation and characteristic facies · score 0.53
- genetic disorder · score 0.47
- Global developmental delay · score 0.41
- Cerebellar atrophy · score 0.41
- Retinal dystrophy · score 0.38
- global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome · score 0.37
- autosomal recessive retinitis pigmentosa · score 0.33
- congenital hydronephrosis · score 0.27
- congenital anomaly of kidney and urinary tract · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N766-F1 | alphafold | PREDICTED | 87.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N766.
Amino-acid sequence (993 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EMC1?
The strongest Open Targets associations for EMC1 are cerebellar atrophy, visual impairment, and psychomotor retardation;, hypotonia, infantile, with psychomotor retardation and characteristic facies, genetic disorder, Global developmental delay and Cerebellar atrophy.
How long is the EMC1 protein?
The Homo sapiens EMC1 protein (UniProt Q8N766) is 993 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N766 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N766 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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