Kelch domain-containing protein 1 (KLHDC1)
Homo sapiens — UniProt Q8N7A1
Data last refreshed: (UniProt release unknown)
Key facts
Kelch domain-containing protein 1 (KLHDC1) is a protein from Homo sapiens identified by UniProt accession Q8N7A1, 406 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.
- UniProt accession: Q8N7A1; gene symbol KLHDC1.
- Organism: Homo sapiens.
- Length: 406 amino acids.
- Top disease associations (Open Targets): metabolite measurement, facial asymmetry measurement and serum gamma-glutamyl transferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch domain-containing protein 1 |
|---|---|
| UniProt accession | Q8N7A1 |
| Gene | KLHDC1 |
| Organism | Homo sapiens |
| Length | 406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (21)
Diseases linked to this target (Open Targets).
- metabolite measurement · score 0.26
- facial asymmetry measurement · score 0.23
- serum gamma-glutamyl transferase measurement · score 0.11
- eicosadienoic acid measurement · score 0.04
- C-reactive protein measurement · score 0.04
- fatty acid measurement · score 0.04
- ovarian carcinoma · score 0.02
- lung adenocarcinoma · score 0.01
- type 2 diabetes mellitus · score 0.01
- Sepsis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7A1-F1 | alphafold | PREDICTED | 93.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7A1.
Amino-acid sequence (406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHDC1?
The strongest Open Targets associations for KLHDC1 are metabolite measurement, facial asymmetry measurement, serum gamma-glutamyl transferase measurement, eicosadienoic acid measurement and C-reactive protein measurement.
How long is the KLHDC1 protein?
The Homo sapiens KLHDC1 protein (UniProt Q8N7A1) is 406 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7A1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7A1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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