HORMA domain-containing protein 2 (HORMAD2)
Homo sapiens — UniProt Q8N7B1
Data last refreshed: (UniProt release unknown)
Key facts
HORMA domain-containing protein 2 (HORMAD2) is a protein from Homo sapiens identified by UniProt accession Q8N7B1, 307 residues long. MolForge cross-references it against 0 known binders and 187 disease associations.
- UniProt accession: Q8N7B1; gene symbol HORMAD2.
- Organism: Homo sapiens.
- Length: 307 amino acids.
- Top disease associations (Open Targets): lymphocyte count, lymphocyte percentage of leukocytes and hypothyroidism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | HORMA domain-containing protein 2 |
|---|---|
| UniProt accession | Q8N7B1 |
| Gene | HORMAD2 |
| Organism | Homo sapiens |
| Length | 307 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (187)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.47
- lymphocyte percentage of leukocytes · score 0.41
- hypothyroidism · score 0.40
- Hashimoto's thyroiditis · score 0.39
- total blood protein measurement · score 0.38
- cup-to-disc ratio measurement · score 0.36
- mean corpuscular volume · score 0.36
- body height · score 0.36
- IGA glomerulonephritis · score 0.35
- vital capacity · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7B1-F1 | alphafold | PREDICTED | 71.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7B1.
Amino-acid sequence (307 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HORMAD2?
The strongest Open Targets associations for HORMAD2 are lymphocyte count, lymphocyte percentage of leukocytes, hypothyroidism, Hashimoto's thyroiditis and total blood protein measurement.
How long is the HORMAD2 protein?
The Homo sapiens HORMAD2 protein (UniProt Q8N7B1) is 307 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7B1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7B1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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