EF-hand calcium-binding domain-containing protein 3 (EFCAB3)
Homo sapiens — UniProt Q8N7B9
Data last refreshed: (UniProt release unknown)
Key facts
EF-hand calcium-binding domain-containing protein 3 (EFCAB3) is a protein from Homo sapiens identified by UniProt accession Q8N7B9, 438 residues long. MolForge cross-references it against 0 known binders and 6 disease associations.
- UniProt accession: Q8N7B9; gene symbol EFCAB3.
- Organism: Homo sapiens.
- Length: 438 amino acids.
- Top disease associations (Open Targets): hypothyroidism, body height and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | EF-hand calcium-binding domain-containing protein 3 |
|---|---|
| UniProt accession | Q8N7B9 |
| Gene | EFCAB3 |
| Organism | Homo sapiens |
| Length | 438 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (6)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.29
- body height · score 0.07
- mean corpuscular volume · score 0.04
- Chudley-McCullough syndrome · score 0.03
- cancer · score 0.00
- achalasia-alacrima syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7B9-F1 | alphafold | PREDICTED | 65.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7B9.
Amino-acid sequence (438 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EFCAB3?
The strongest Open Targets associations for EFCAB3 are hypothyroidism, body height, mean corpuscular volume, Chudley-McCullough syndrome and cancer.
How long is the EFCAB3 protein?
The Homo sapiens EFCAB3 protein (UniProt Q8N7B9) is 438 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7B9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7B9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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