Transmembrane protein 217 (TMEM217)
Homo sapiens — UniProt Q8N7C4
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 217 (TMEM217) is a protein from Homo sapiens identified by UniProt accession Q8N7C4, 229 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q8N7C4; gene symbol TMEM217.
- Organism: Homo sapiens.
- Length: 229 amino acids.
- Top disease associations (Open Targets): platelet count, platelet crit and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 217 |
|---|---|
| UniProt accession | Q8N7C4 |
| Gene | TMEM217 |
| Organism | Homo sapiens |
| Length | 229 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- platelet count · score 0.26
- platelet crit · score 0.14
- body height · score 0.12
- mean reticulocyte volume · score 0.08
- indoxyl sulfate measurement · score 0.07
- breast carcinoma · score 0.04
- sex hormone-binding globulin measurement · score 0.04
- mean corpuscular hemoglobin · score 0.04
- neutrophil count · score 0.03
- mean corpuscular volume · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7C4-F1 | alphafold | PREDICTED | 71.71 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7C4.
Amino-acid sequence (229 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM217?
The strongest Open Targets associations for TMEM217 are platelet count, platelet crit, body height, mean reticulocyte volume and indoxyl sulfate measurement.
How long is the TMEM217 protein?
The Homo sapiens TMEM217 protein (UniProt Q8N7C4) is 229 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7C4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7C4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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