RING finger protein 148 (RNF148)
Homo sapiens — UniProt Q8N7C7
Data last refreshed: (UniProt release unknown)
Key facts
RING finger protein 148 (RNF148) is a protein from Homo sapiens identified by UniProt accession Q8N7C7, 305 residues long. MolForge cross-references it against 0 known binders and 4 disease associations.
- UniProt accession: Q8N7C7; gene symbol RNF148.
- Organism: Homo sapiens.
- Length: 305 amino acids.
- Top disease associations (Open Targets): X-linked intellectual disability-psychosis-macroorchidism syndrome, age at menarche and schizophrenia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RING finger protein 148 |
|---|---|
| UniProt accession | Q8N7C7 |
| Gene | RNF148 |
| Organism | Homo sapiens |
| Length | 305 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (4)
Diseases linked to this target (Open Targets).
- X-linked intellectual disability-psychosis-macroorchidism syndrome · score 0.03
- age at menarche · score 0.03
- schizophrenia · score 0.00
- Colon Sessile Serrated Adenoma/Polyp · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7C7-F1 | alphafold | PREDICTED | 86.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7C7.
Amino-acid sequence (305 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF148?
The strongest Open Targets associations for RNF148 are X-linked intellectual disability-psychosis-macroorchidism syndrome, age at menarche, schizophrenia and Colon Sessile Serrated Adenoma/Polyp.
How long is the RNF148 protein?
The Homo sapiens RNF148 protein (UniProt Q8N7C7) is 305 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7C7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7C7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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