E3 ubiquitin-protein ligase CBLL2 (CBLL2)
Homo sapiens — UniProt Q8N7E2
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase CBLL2 (CBLL2) is a protein from Homo sapiens identified by UniProt accession Q8N7E2, 425 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q8N7E2; gene symbol CBLL2.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): X-linked dominant hypophosphatemic rickets, X-linked hypophosphatemia and colorectal adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase CBLL2 |
|---|---|
| UniProt accession | Q8N7E2 |
| Gene | CBLL2 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- X-linked dominant hypophosphatemic rickets · score 0.46
- X-linked hypophosphatemia · score 0.46
- colorectal adenocarcinoma · score 0.04
- pancreatic adenocarcinoma · score 0.04
- non-small cell lung carcinoma · score 0.03
- carcinoma of liver and intrahepatic biliary tract · score 0.01
- cancer · score 0.01
- lung carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7E2-F1 | alphafold | PREDICTED | 55.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7E2.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CBLL2?
The strongest Open Targets associations for CBLL2 are X-linked dominant hypophosphatemic rickets, X-linked hypophosphatemia, colorectal adenocarcinoma, pancreatic adenocarcinoma and non-small cell lung carcinoma.
How long is the CBLL2 protein?
The Homo sapiens CBLL2 protein (UniProt Q8N7E2) is 425 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7E2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7E2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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