POU domain, class 5, transcription factor 2 (POU5F2)
Homo sapiens — UniProt Q8N7G0
Data last refreshed: (UniProt release unknown)
Key facts
POU domain, class 5, transcription factor 2 (POU5F2) is a protein from Homo sapiens identified by UniProt accession Q8N7G0, 328 residues long. MolForge cross-references it against 0 known binders and 37 disease associations.
- UniProt accession: Q8N7G0; gene symbol POU5F2.
- Organism: Homo sapiens.
- Length: 328 amino acids.
- Top disease associations (Open Targets): cortical surface area measurement, self reported educational attainment and neuroimaging measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | POU domain, class 5, transcription factor 2 |
|---|---|
| UniProt accession | Q8N7G0 |
| Gene | POU5F2 |
| Organism | Homo sapiens |
| Length | 328 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (37)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.19
- self reported educational attainment · score 0.18
- neuroimaging measurement · score 0.18
- unipolar depression · score 0.17
- insomnia measurement · score 0.15
- brain measurement · score 0.15
- age at menarche · score 0.14
- metabolite measurement · score 0.14
- mathematical ability · score 0.14
- diet measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7G0-F1 | alphafold | PREDICTED | 61.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7G0.
Amino-acid sequence (328 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POU5F2?
The strongest Open Targets associations for POU5F2 are cortical surface area measurement, self reported educational attainment, neuroimaging measurement, unipolar depression and insomnia measurement.
How long is the POU5F2 protein?
The Homo sapiens POU5F2 protein (UniProt Q8N7G0) is 328 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7G0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7G0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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