RNA polymerase II-associated factor 1 homolog (PAF1)
Homo sapiens — UniProt Q8N7H5
Data last refreshed: (UniProt release unknown)
Key facts
RNA polymerase II-associated factor 1 homolog (PAF1) is a protein from Homo sapiens identified by UniProt accession Q8N7H5, 531 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.
- UniProt accession: Q8N7H5; gene symbol PAF1.
- Organism: Homo sapiens.
- Length: 531 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Parkinson disease and Alzheimer disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA polymerase II-associated factor 1 homolog |
|---|---|
| UniProt accession | Q8N7H5 |
| Gene | PAF1 |
| Organism | Homo sapiens |
| Length | 531 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- Parkinson disease · score 0.46
- Alzheimer disease · score 0.46
- lysosomal storage disease · score 0.46
- multiple sclerosis · score 0.46
- peroxisome biogenesis disorder 1A (Zellweger) · score 0.12
- pancreatic neoplasm · score 0.09
- neoplasm · score 0.09
- cancer · score 0.08
- hepatocellular carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7H5-F1 | alphafold | PREDICTED | 66.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7H5.
Amino-acid sequence (531 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PAF1?
The strongest Open Targets associations for PAF1 are neurodegenerative disease, Parkinson disease, Alzheimer disease, lysosomal storage disease and multiple sclerosis.
How long is the PAF1 protein?
The Homo sapiens PAF1 protein (UniProt Q8N7H5) is 531 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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