APC membrane recruitment protein 2 (AMER2)
Homo sapiens — UniProt Q8N7J2
Data last refreshed: (UniProt release unknown)
Key facts
APC membrane recruitment protein 2 (AMER2) is a protein from Homo sapiens identified by UniProt accession Q8N7J2, 671 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.
- UniProt accession: Q8N7J2; gene symbol AMER2.
- Organism: Homo sapiens.
- Length: 671 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, proline measurement and Ataxia-telangiectasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | APC membrane recruitment protein 2 |
|---|---|
| UniProt accession | Q8N7J2 |
| Gene | AMER2 |
| Organism | Homo sapiens |
| Length | 671 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (10)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- proline measurement · score 0.25
- Ataxia-telangiectasia · score 0.02
- atypical teratoid rhabdoid tumor · score 0.02
- Alzheimer disease · score 0.01
- cancer · score 0.01
- astrocytoma · score 0.01
- neoplasm · score 0.01
- glioblastoma multiforme · score 0.00
- Sjogren syndrome · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7J2-F1 | alphafold | PREDICTED | 51.21 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7J2.
Amino-acid sequence (671 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AMER2?
The strongest Open Targets associations for AMER2 are neurodegenerative disease, proline measurement, Ataxia-telangiectasia, atypical teratoid rhabdoid tumor and Alzheimer disease.
How long is the AMER2 protein?
The Homo sapiens AMER2 protein (UniProt Q8N7J2) is 671 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7J2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7J2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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