DnaJ homolog subfamily C member 5G (DNAJC5G)
Homo sapiens — UniProt Q8N7S2
Data last refreshed: (UniProt release unknown)
Key facts
DnaJ homolog subfamily C member 5G (DNAJC5G) is a protein from Homo sapiens identified by UniProt accession Q8N7S2, 189 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q8N7S2; gene symbol DNAJC5G.
- Organism: Homo sapiens.
- Length: 189 amino acids.
- Top disease associations (Open Targets): MODY, hyperinsulinism due to INSR deficiency and hyperproinsulinemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DnaJ homolog subfamily C member 5G |
|---|---|
| UniProt accession | Q8N7S2 |
| Gene | DNAJC5G |
| Organism | Homo sapiens |
| Length | 189 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- MODY · score 0.07
- hyperinsulinism due to INSR deficiency · score 0.07
- hyperproinsulinemia · score 0.07
- hyperinsulinism due to glucokinase deficiency · score 0.06
- microphthalmia · score 0.06
- exercise-induced hyperinsulinism · score 0.06
- nanophthalmos 2 · score 0.05
- nanophthalmia · score 0.05
- hyperinsulinism-hyperammonemia syndrome · score 0.04
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7S2-F1 | alphafold | PREDICTED | 69.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7S2.
Amino-acid sequence (189 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DNAJC5G?
The strongest Open Targets associations for DNAJC5G are MODY, hyperinsulinism due to INSR deficiency, hyperproinsulinemia, hyperinsulinism due to glucokinase deficiency and microphthalmia.
How long is the DNAJC5G protein?
The Homo sapiens DNAJC5G protein (UniProt Q8N7S2) is 189 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7S2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7S2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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