RNA-binding motif protein, X-linked-like-3 (RBMXL3)
Homo sapiens — UniProt Q8N7X1
Data last refreshed: (UniProt release unknown)
Key facts
RNA-binding motif protein, X-linked-like-3 (RBMXL3) is a protein from Homo sapiens identified by UniProt accession Q8N7X1, 1067 residues long. MolForge cross-references it against 0 known binders and 89 disease associations.
- UniProt accession: Q8N7X1; gene symbol RBMXL3.
- Organism: Homo sapiens.
- Length: 1067 amino acids.
- Top disease associations (Open Targets): Kleine-Levin Syndrome, azoospermia and male infertility with teratozoospermia due to single gene mutation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA-binding motif protein, X-linked-like-3 |
|---|---|
| UniProt accession | Q8N7X1 |
| Gene | RBMXL3 |
| Organism | Homo sapiens |
| Length | 1067 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (89)
Diseases linked to this target (Open Targets).
- Kleine-Levin Syndrome · score 0.11
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.07
- spermatogenic failure 25 · score 0.06
- spermatogenic failures 50 · score 0.06
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failure, X-linked, 2 · score 0.06
- isochromosomy Yp · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N7X1-F1 | alphafold | PREDICTED | 40.80 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N7X1.
Amino-acid sequence (1067 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RBMXL3?
The strongest Open Targets associations for RBMXL3 are Kleine-Levin Syndrome, azoospermia, male infertility with teratozoospermia due to single gene mutation, partial chromosome Y deletion and spermatogenic failure 25.
How long is the RBMXL3 protein?
The Homo sapiens RBMXL3 protein (UniProt Q8N7X1) is 1067 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N7X1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N7X1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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