Sperm-associated microtubule inner protein 4 (SPMIP4)
Homo sapiens — UniProt Q8N865
Data last refreshed: (UniProt release unknown)
Key facts
Sperm-associated microtubule inner protein 4 (SPMIP4) is a protein from Homo sapiens identified by UniProt accession Q8N865, 590 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q8N865; gene symbol SPMIP4.
- Organism: Homo sapiens.
- Length: 590 amino acids.
- Top disease associations (Open Targets): neurofibrillary tangles measurement, body fat percentage and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sperm-associated microtubule inner protein 4 |
|---|---|
| UniProt accession | Q8N865 |
| Gene | SPMIP4 |
| Organism | Homo sapiens |
| Length | 590 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.26
- body fat percentage · score 0.24
- heel bone mineral density · score 0.23
- body height · score 0.23
- bone quantitative ultrasound measurement · score 0.21
- hemoglobin measurement · score 0.20
- hematocrit · score 0.18
- lobe attachment · score 0.16
- erythrocyte count · score 0.12
- BMI-adjusted waist circumference · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N865-F1 | alphafold | PREDICTED | 58.25 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N865.
Amino-acid sequence (590 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPMIP4?
The strongest Open Targets associations for SPMIP4 are neurofibrillary tangles measurement, body fat percentage, heel bone mineral density, body height and bone quantitative ultrasound measurement.
How long is the SPMIP4 protein?
The Homo sapiens SPMIP4 protein (UniProt Q8N865) is 590 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N865 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N865 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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