Centrosomal protein of 112 kDa (CEP112)
Homo sapiens — UniProt Q8N8E3
Data last refreshed: (UniProt release unknown)
Key facts
Centrosomal protein of 112 kDa (CEP112) is a protein from Homo sapiens identified by UniProt accession Q8N8E3, 955 residues long. MolForge cross-references it against 0 known binders and 74 disease associations.
- UniProt accession: Q8N8E3; gene symbol CEP112.
- Organism: Homo sapiens.
- Length: 955 amino acids.
- Top disease associations (Open Targets): spermatogenic failure 44, blood protein measurement and cortical surface area measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centrosomal protein of 112 kDa |
|---|---|
| UniProt accession | Q8N8E3 |
| Gene | CEP112 |
| Organism | Homo sapiens |
| Length | 955 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (74)
Diseases linked to this target (Open Targets).
- spermatogenic failure 44 · score 0.55
- blood protein measurement · score 0.47
- cortical surface area measurement · score 0.45
- neuroimaging measurement · score 0.43
- brain measurement · score 0.40
- platelet count · score 0.37
- cortical thickness · score 0.37
- hair shape measurement · score 0.36
- aspartate aminotransferase measurement · score 0.35
- serum alanine aminotransferase measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8E3-F1 | alphafold | PREDICTED | 75.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8E3.
Amino-acid sequence (955 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CEP112?
The strongest Open Targets associations for CEP112 are spermatogenic failure 44, blood protein measurement, cortical surface area measurement, neuroimaging measurement and brain measurement.
How long is the CEP112 protein?
The Homo sapiens CEP112 protein (UniProt Q8N8E3) is 955 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8E3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8E3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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