Sterile alpha motif domain-containing protein 12 (SAMD12)
Homo sapiens — UniProt Q8N8I0
Data last refreshed: (UniProt release unknown)
Key facts
Sterile alpha motif domain-containing protein 12 (SAMD12) is a protein from Homo sapiens identified by UniProt accession Q8N8I0, 201 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q8N8I0; gene symbol SAMD12.
- Organism: Homo sapiens.
- Length: 201 amino acids.
- Top disease associations (Open Targets): benign adult familial myoclonic epilepsy, self reported educational attainment and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sterile alpha motif domain-containing protein 12 |
|---|---|
| UniProt accession | Q8N8I0 |
| Gene | SAMD12 |
| Organism | Homo sapiens |
| Length | 201 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- benign adult familial myoclonic epilepsy · score 0.62
- self reported educational attainment · score 0.39
- eosinophil count · score 0.37
- lymphocyte percentage of leukocytes · score 0.33
- osteoprotegerin measurement · score 0.32
- mathematical ability · score 0.31
- risk-taking behaviour · score 0.30
- heel bone mineral density · score 0.30
- neurofibrillary tangles measurement · score 0.26
- alkaline phosphatase measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8I0-F1 | alphafold | PREDICTED | 71.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8I0.
Amino-acid sequence (201 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SAMD12?
The strongest Open Targets associations for SAMD12 are benign adult familial myoclonic epilepsy, self reported educational attainment, eosinophil count, lymphocyte percentage of leukocytes and osteoprotegerin measurement.
How long is the SAMD12 protein?
The Homo sapiens SAMD12 protein (UniProt Q8N8I0) is 201 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8I0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8I0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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