Zinc finger protein 491 (ZNF491)

About Zinc finger protein 491

Zinc finger protein 491 (ZNF491) is a protein from Homo sapiens identified by UniProt accession Q8N8L2, 437 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Zinc finger protein 491
UniProt accession	Q8N8L2
Gene	ZNF491
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

vitamin D measurement · score 0.09
blood phosphate measurement · score 0.07
neutrophil count · score 0.07
leukocyte count · score 0.07
IGF-1 measurement · score 0.04
myeloid white cell count · score 0.04
eosinophil count · score 0.03
neoplasm · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q8N8L2-F1	alphafold	PREDICTED	76.26	—

Amino-acid sequence (437 residues)

MGERLFESAE GSQCGETFTQ VPEDMLNKKT LPGVKSCESG TCGEIFMGYS SFNRNIRTDT GHQPHKCQKF LEKPYKHKQR RKALSHSHCF RTHERPHTRE KPFDCKECEK SFISPASIRR YMVTHSGDGP YKCKFCGKAL DCLSLYLTHE RTHTGEKRYE CKQCGKAFSW HSSVRIHERT HTGEKPYECK ECGKSFNFSS SFRRHERTHT GEKPYKCKEC GKAFNCPSSF HRHERTHTGE KPYECKLYGK ALSRLISFRR HMRMHTGERP HKCKICGKAF YSPSSFQRHE RSHTGEKPYK CKQCGKAFTC STSFQYHERT HTGEKPDGCK QCGKAFRSAK YIRIHGRTHT GEKPYECKQC GKAFHCVSSF HRHERTHAGE KPYECKHCGK AFTCSIYIRI HERIHTGEKP YQCKECGKAF IRSSYCRKHE RTHTINI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards