Zinc finger protein 491 (ZNF491)
Homo sapiens — UniProt Q8N8L2
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 491 (ZNF491) is a protein from Homo sapiens identified by UniProt accession Q8N8L2, 437 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.
- UniProt accession: Q8N8L2; gene symbol ZNF491.
- Organism: Homo sapiens.
- Length: 437 amino acids.
- Top disease associations (Open Targets): vitamin D measurement, blood phosphate measurement and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 491 |
|---|---|
| UniProt accession | Q8N8L2 |
| Gene | ZNF491 |
| Organism | Homo sapiens |
| Length | 437 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (8)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.09
- blood phosphate measurement · score 0.07
- neutrophil count · score 0.07
- leukocyte count · score 0.07
- IGF-1 measurement · score 0.04
- myeloid white cell count · score 0.04
- eosinophil count · score 0.03
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8L2-F1 | alphafold | PREDICTED | 76.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8L2.
Amino-acid sequence (437 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF491?
The strongest Open Targets associations for ZNF491 are vitamin D measurement, blood phosphate measurement, neutrophil count, leukocyte count and IGF-1 measurement.
How long is the ZNF491 protein?
The Homo sapiens ZNF491 protein (UniProt Q8N8L2) is 437 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8L2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8L2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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