E3 ubiquitin-protein ligase RNF152 (RNF152)
Homo sapiens — UniProt Q8N8N0
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase RNF152 (RNF152) is a protein from Homo sapiens identified by UniProt accession Q8N8N0, 203 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q8N8N0; gene symbol RNF152.
- Organism: Homo sapiens.
- Length: 203 amino acids.
- Top disease associations (Open Targets): glomerular filtration rate, creatinine measurement and metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase RNF152 |
|---|---|
| UniProt accession | Q8N8N0 |
| Gene | RNF152 |
| Organism | Homo sapiens |
| Length | 203 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- glomerular filtration rate · score 0.33
- creatinine measurement · score 0.29
- metabolite measurement · score 0.28
- glucuronate measurement · score 0.22
- alkaline phosphatase measurement · score 0.13
- sex hormone-binding globulin measurement · score 0.09
- drug use measurement · score 0.08
- reticulocyte count · score 0.08
- hepatocellular carcinoma · score 0.08
- neoplasm · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8N0-F1 | alphafold | PREDICTED | 66.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8N0.
Amino-acid sequence (203 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF152?
The strongest Open Targets associations for RNF152 are glomerular filtration rate, creatinine measurement, metabolite measurement, glucuronate measurement and alkaline phosphatase measurement.
How long is the RNF152 protein?
The Homo sapiens RNF152 protein (UniProt Q8N8N0) is 203 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8N0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8N0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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