Endonuclease V (ENDOV)
Homo sapiens — UniProt Q8N8Q3
Data last refreshed: (UniProt release unknown)
Key facts
Endonuclease V (ENDOV) is a protein from Homo sapiens identified by UniProt accession Q8N8Q3, 282 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q8N8Q3; gene symbol ENDOV.
- Organism: Homo sapiens.
- Length: 282 amino acids.
- Top disease associations (Open Targets): aspartate aminotransferase measurement, Moyamoya disease and serum alanine aminotransferase measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endonuclease V |
|---|---|
| UniProt accession | Q8N8Q3 |
| Gene | ENDOV |
| Organism | Homo sapiens |
| Length | 282 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- aspartate aminotransferase measurement · score 0.15
- Moyamoya disease · score 0.14
- serum alanine aminotransferase measurement · score 0.12
- mean reticulocyte volume · score 0.09
- isolated asymptomatic elevation of creatine phosphokinase · score 0.05
- pentosuria · score 0.04
- congenital lethal erythroderma · score 0.03
- neoplasm · score 0.02
- hepatocellular carcinoma · score 0.02
- xeroderma pigmentosum · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8Q3-F1 | alphafold | PREDICTED | 90.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8Q3.
Amino-acid sequence (282 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ENDOV?
The strongest Open Targets associations for ENDOV are aspartate aminotransferase measurement, Moyamoya disease, serum alanine aminotransferase measurement, mean reticulocyte volume and isolated asymptomatic elevation of creatine phosphokinase.
How long is the ENDOV protein?
The Homo sapiens ENDOV protein (UniProt Q8N8Q3) is 282 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8Q3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8Q3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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