Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18)
Homo sapiens — UniProt Q8N8Q8
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase assembly protein COX18, mitochondrial (COX18) is a protein from Homo sapiens identified by UniProt accession Q8N8Q8, 333 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q8N8Q8; gene symbol COX18.
- Organism: Homo sapiens.
- Length: 333 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, prostate carcinoma and low density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase assembly protein COX18, mitochondrial |
|---|---|
| UniProt accession | Q8N8Q8 |
| Gene | COX18 |
| Organism | Homo sapiens |
| Length | 333 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- prostate carcinoma · score 0.21
- low density lipoprotein cholesterol measurement · score 0.20
- lung adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- endometrial cancer · score 0.18
- appendicular lean mass · score 0.18
- vitamin D measurement · score 0.18
- esophageal cancer · score 0.15
- gastric adenocarcinoma · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8Q8-F1 | alphafold | PREDICTED | 83.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8Q8.
Amino-acid sequence (333 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COX18?
The strongest Open Targets associations for COX18 are neurodegenerative disease, prostate carcinoma, low density lipoprotein cholesterol measurement, lung adenocarcinoma and head and neck squamous cell carcinoma.
How long is the COX18 protein?
The Homo sapiens COX18 protein (UniProt Q8N8Q8) is 333 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8Q8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8Q8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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