Mitochondrial basic amino acids transporter (SLC25A29)
Homo sapiens — UniProt Q8N8R3
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial basic amino acids transporter (SLC25A29) is a protein from Homo sapiens identified by UniProt accession Q8N8R3, 303 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q8N8R3; gene symbol SLC25A29.
- Organism: Homo sapiens.
- Length: 303 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): neurodegenerative disease, creatinine measurement and glomerular filtration rate.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial basic amino acids transporter |
|---|---|
| UniProt accession | Q8N8R3 |
| Gene | SLC25A29 |
| Organism | Homo sapiens |
| Length | 303 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- creatinine measurement · score 0.32
- glomerular filtration rate · score 0.31
- triglyceride measurement · score 0.29
- high density lipoprotein cholesterol measurement · score 0.14
- sex hormone-binding globulin measurement · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.06
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.06
- primary familial polycythemia due to EPO receptor mutation · score 0.06
- Pyruvate kinase hyperactivity · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8R3-F1 | alphafold | PREDICTED | 80.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8R3.
Amino-acid sequence (303 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC25A29?
The strongest Open Targets associations for SLC25A29 are neurodegenerative disease, creatinine measurement, glomerular filtration rate, triglyceride measurement and high density lipoprotein cholesterol measurement.
How long is the SLC25A29 protein?
The Homo sapiens SLC25A29 protein (UniProt Q8N8R3) is 303 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8R3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8R3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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