Retrotransposon Gag-like protein 3 (RTL3)
Homo sapiens — UniProt Q8N8U3
Data last refreshed: (UniProt release unknown)
Key facts
Retrotransposon Gag-like protein 3 (RTL3) is a protein from Homo sapiens identified by UniProt accession Q8N8U3, 475 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q8N8U3; gene symbol RTL3.
- Organism: Homo sapiens.
- Length: 475 amino acids.
- Top disease associations (Open Targets): major depressive disorder, attention deficit hyperactivity disorder and obsessive-compulsive disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Retrotransposon Gag-like protein 3 |
|---|---|
| UniProt accession | Q8N8U3 |
| Gene | RTL3 |
| Organism | Homo sapiens |
| Length | 475 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- major depressive disorder · score 0.07
- attention deficit hyperactivity disorder · score 0.06
- obsessive-compulsive disorder · score 0.06
- viral disease · score 0.01
- spinal muscular atrophy · score 0.01
- severe malarial anemia · score 0.01
- spinal muscular atrophy, type 1 · score 0.00
- Adams-Oliver syndrome · score 0.00
- infect · score 0.00
- neoplasm · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8U3-F1 | alphafold | PREDICTED | 58.87 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8U3.
Amino-acid sequence (475 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RTL3?
The strongest Open Targets associations for RTL3 are major depressive disorder, attention deficit hyperactivity disorder, obsessive-compulsive disorder, viral disease and spinal muscular atrophy.
How long is the RTL3 protein?
The Homo sapiens RTL3 protein (UniProt Q8N8U3) is 475 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8U3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8U3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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