BMP-binding endothelial regulator protein (BMPER)
Homo sapiens — UniProt Q8N8U9
Data last refreshed: (UniProt release unknown)
Key facts
BMP-binding endothelial regulator protein (BMPER) is a protein from Homo sapiens identified by UniProt accession Q8N8U9, 685 residues long. MolForge cross-references it against 0 known binders and 178 disease associations.
- UniProt accession: Q8N8U9; gene symbol BMPER.
- Organism: Homo sapiens.
- Length: 685 amino acids.
- Top disease associations (Open Targets): diaphanospondylodysostosis, sensorineural hearing loss and disorder of ear.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BMP-binding endothelial regulator protein |
|---|---|
| UniProt accession | Q8N8U9 |
| Gene | BMPER |
| Organism | Homo sapiens |
| Length | 685 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (178)
Diseases linked to this target (Open Targets).
- diaphanospondylodysostosis · score 0.75
- sensorineural hearing loss · score 0.40
- disorder of ear · score 0.40
- neurodegenerative disease · score 0.37
- vital capacity · score 0.37
- refractive error measurement · score 0.36
- longevity · score 0.31
- body height · score 0.30
- Abnormal mastoid morphology · score 0.30
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8U9-F1 | alphafold | PREDICTED | 79.91 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8U9.
Amino-acid sequence (685 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BMPER?
The strongest Open Targets associations for BMPER are diaphanospondylodysostosis, sensorineural hearing loss, disorder of ear, neurodegenerative disease and vital capacity.
How long is the BMPER protein?
The Homo sapiens BMPER protein (UniProt Q8N8U9) is 685 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8U9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8U9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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