Guanylate-binding protein 7 (GBP7)
Homo sapiens — UniProt Q8N8V2
Data last refreshed: (UniProt release unknown)
Key facts
Guanylate-binding protein 7 (GBP7) is a protein from Homo sapiens identified by UniProt accession Q8N8V2, 638 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q8N8V2; gene symbol GBP7.
- Organism: Homo sapiens.
- Length: 638 amino acids.
- Top disease associations (Open Targets): pancreatic adenocarcinoma, Immunodeficiency due to a late component of complements deficiency and recurrent Neisseria infections due to factor D deficiency.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanylate-binding protein 7 |
|---|---|
| UniProt accession | Q8N8V2 |
| Gene | GBP7 |
| Organism | Homo sapiens |
| Length | 638 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- pancreatic adenocarcinoma · score 0.18
- Immunodeficiency due to a late component of complements deficiency · score 0.10
- recurrent Neisseria infections due to factor D deficiency · score 0.07
- immunodeficiency 28 · score 0.07
- isolated asymptomatic elevation of creatine phosphokinase · score 0.07
- varicella, severe recurrent · score 0.07
- candidiasis, familial, 4 · score 0.06
- immunodeficiency 31B · score 0.06
- type II complement component 8 deficiency · score 0.06
- Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8V2-F1 | alphafold | PREDICTED | 86.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8V2.
Amino-acid sequence (638 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GBP7?
The strongest Open Targets associations for GBP7 are pancreatic adenocarcinoma, Immunodeficiency due to a late component of complements deficiency, recurrent Neisseria infections due to factor D deficiency, immunodeficiency 28 and isolated asymptomatic elevation of creatine phosphokinase.
How long is the GBP7 protein?
The Homo sapiens GBP7 protein (UniProt Q8N8V2) is 638 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8V2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8V2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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