Ankyrin repeat and SAM domain-containing protein 4B (ANKS4B)
Homo sapiens — UniProt Q8N8V4
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat and SAM domain-containing protein 4B (ANKS4B) is a protein from Homo sapiens identified by UniProt accession Q8N8V4, 417 residues long. MolForge cross-references it against 0 known binders and 62 disease associations.
- UniProt accession: Q8N8V4; gene symbol ANKS4B.
- Organism: Homo sapiens.
- Length: 417 amino acids.
- Top disease associations (Open Targets): Barrett's esophagus, Hypomaturation amelogenesis imperfecta and Hypoplastic amelogenesis imperfecta.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat and SAM domain-containing protein 4B |
|---|---|
| UniProt accession | Q8N8V4 |
| Gene | ANKS4B |
| Organism | Homo sapiens |
| Length | 417 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (62)
Diseases linked to this target (Open Targets).
- Barrett's esophagus · score 0.08
- Hypomaturation amelogenesis imperfecta · score 0.08
- Hypoplastic amelogenesis imperfecta · score 0.07
- esophageal adenocarcinoma · score 0.06
- tooth agenesis · score 0.06
- dentin dysplasia type I · score 0.05
- amelogenesis imperfecta, type ij · score 0.05
- dentin dysplasia type II · score 0.05
- amelogenesis imperfecta · score 0.05
- dentinogenesis imperfecta type 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8V4-F1 | alphafold | PREDICTED | 70.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8V4.
Amino-acid sequence (417 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKS4B?
The strongest Open Targets associations for ANKS4B are Barrett's esophagus, Hypomaturation amelogenesis imperfecta, Hypoplastic amelogenesis imperfecta, esophageal adenocarcinoma and tooth agenesis.
How long is the ANKS4B protein?
The Homo sapiens ANKS4B protein (UniProt Q8N8V4) is 417 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8V4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8V4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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