Omega-hydroxyceramide transacylase (PNPLA1)
Homo sapiens — UniProt Q8N8W4
Data last refreshed: (UniProt release unknown)
Key facts
Omega-hydroxyceramide transacylase (PNPLA1) is a protein from Homo sapiens identified by UniProt accession Q8N8W4, 532 residues long. MolForge cross-references it against 0 known binders and 77 disease associations.
- UniProt accession: Q8N8W4; gene symbol PNPLA1.
- Organism: Homo sapiens.
- Length: 532 amino acids.
- Top disease associations (Open Targets): congenital non-bullous ichthyosiform erythroderma, congenital reticular ichthyosiform erythroderma and inherited ichthyosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Omega-hydroxyceramide transacylase |
|---|---|
| UniProt accession | Q8N8W4 |
| Gene | PNPLA1 |
| Organism | Homo sapiens |
| Length | 532 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (77)
Diseases linked to this target (Open Targets).
- congenital non-bullous ichthyosiform erythroderma · score 0.68
- congenital reticular ichthyosiform erythroderma · score 0.53
- inherited ichthyosis · score 0.46
- autosomal recessive congenital ichthyosis · score 0.38
- lamellar ichthyosis · score 0.37
- body height · score 0.36
- ichthyosis · score 0.34
- hematocrit · score 0.31
- red blood cell density measurement · score 0.30
- erythrocyte count · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N8W4-F1 | alphafold | PREDICTED | 63.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N8W4.
Amino-acid sequence (532 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PNPLA1?
The strongest Open Targets associations for PNPLA1 are congenital non-bullous ichthyosiform erythroderma, congenital reticular ichthyosiform erythroderma, inherited ichthyosis, autosomal recessive congenital ichthyosis and lamellar ichthyosis.
How long is the PNPLA1 protein?
The Homo sapiens PNPLA1 protein (UniProt Q8N8W4) is 532 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N8W4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N8W4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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