Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC)
Homo sapiens — UniProt Q8N912
Data last refreshed: (UniProt release unknown)
Key facts
Nutritionally-regulated adipose and cardiac enriched protein homolog (NRAC) is a protein from Homo sapiens identified by UniProt accession Q8N912, 160 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.
- UniProt accession: Q8N912; gene symbol NRAC.
- Organism: Homo sapiens.
- Length: 160 amino acids.
- Top disease associations (Open Targets): brain volume measurement, acalculous cholecystitis and rheumatoid arthritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nutritionally-regulated adipose and cardiac enriched protein homolog |
|---|---|
| UniProt accession | Q8N912 |
| Gene | NRAC |
| Organism | Homo sapiens |
| Length | 160 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (23)
Diseases linked to this target (Open Targets).
- brain volume measurement · score 0.09
- acalculous cholecystitis · score 0.06
- rheumatoid arthritis · score 0.06
- platelet count · score 0.06
- Barrett's esophagus · score 0.05
- hepatocellular carcinoma · score 0.04
- platelet crit · score 0.04
- blood protein measurement · score 0.03
- small cell lung carcinoma · score 0.01
- colorectal adenocarcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N912-F1 | alphafold | PREDICTED | 65.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N912.
Amino-acid sequence (160 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NRAC?
The strongest Open Targets associations for NRAC are brain volume measurement, acalculous cholecystitis, rheumatoid arthritis, platelet count and Barrett's esophagus.
How long is the NRAC protein?
The Homo sapiens NRAC protein (UniProt Q8N912) is 160 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N912 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N912 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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