Ankyrin repeat and fibronectin type-III domain-containing protein 1 (ANKFN1)
Homo sapiens — UniProt Q8N957
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat and fibronectin type-III domain-containing protein 1 (ANKFN1) is a protein from Homo sapiens identified by UniProt accession Q8N957, 1146 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.
- UniProt accession: Q8N957; gene symbol ANKFN1.
- Organism: Homo sapiens.
- Length: 1146 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, body height and bone quantitative ultrasound measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat and fibronectin type-III domain-containing protein 1 |
|---|---|
| UniProt accession | Q8N957 |
| Gene | ANKFN1 |
| Organism | Homo sapiens |
| Length | 1146 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (91)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.45
- body height · score 0.43
- bone quantitative ultrasound measurement · score 0.41
- vital capacity · score 0.39
- appendicular lean mass · score 0.38
- forced expiratory volume · score 0.36
- bone density · score 0.36
- chronotype measurement · score 0.34
- cortical thickness · score 0.29
- cortical surface area measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N957-F1 | alphafold | PREDICTED | 65.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N957.
Amino-acid sequence (1146 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKFN1?
The strongest Open Targets associations for ANKFN1 are heel bone mineral density, body height, bone quantitative ultrasound measurement, vital capacity and appendicular lean mass.
How long is the ANKFN1 protein?
The Homo sapiens ANKFN1 protein (UniProt Q8N957) is 1146 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N957 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N957 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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