Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2)
Homo sapiens — UniProt Q8N961
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) is a protein from Homo sapiens identified by UniProt accession Q8N961, 1025 residues long. MolForge cross-references it against 0 known binders and 32 disease associations.
- UniProt accession: Q8N961; gene symbol ABTB2.
- Organism: Homo sapiens.
- Length: 1025 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, viral load and visual perception measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat and BTB/POZ domain-containing protein 2 |
|---|---|
| UniProt accession | Q8N961 |
| Gene | ABTB2 |
| Organism | Homo sapiens |
| Length | 1025 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (32)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- viral load · score 0.34
- visual perception measurement · score 0.34
- blood protein measurement · score 0.26
- Crigler-Najjar syndrome type 2 · score 0.04
- Gilbert syndrome · score 0.03
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.03
- eosinophil count · score 0.03
- catalase measurement · score 0.02
- breast cancer · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N961-F1 | alphafold | PREDICTED | 76.37 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N961.
Amino-acid sequence (1025 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ABTB2?
The strongest Open Targets associations for ABTB2 are neurodegenerative disease, viral load, visual perception measurement, blood protein measurement and Crigler-Najjar syndrome type 2.
How long is the ABTB2 protein?
The Homo sapiens ABTB2 protein (UniProt Q8N961) is 1025 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N961 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N961 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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