Palmitoyltransferase ZDHHC22 (ZDHHC22)
Homo sapiens — UniProt Q8N966
Data last refreshed: (UniProt release unknown)
Key facts
Palmitoyltransferase ZDHHC22 (ZDHHC22) is a protein from Homo sapiens identified by UniProt accession Q8N966, 263 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q8N966; gene symbol ZDHHC22.
- Organism: Homo sapiens.
- Length: 263 amino acids.
- Top disease associations (Open Targets): Romano-Ward syndrome, smoking behavior and familial atrial fibrillation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Palmitoyltransferase ZDHHC22 |
|---|---|
| UniProt accession | Q8N966 |
| Gene | ZDHHC22 |
| Organism | Homo sapiens |
| Length | 263 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- Romano-Ward syndrome · score 0.07
- smoking behavior · score 0.07
- familial atrial fibrillation · score 0.07
- Familial short QT syndrome · score 0.06
- Brugada syndrome · score 0.06
- Arrhythmogenic right ventricular dysplasia · score 0.06
- Familial progressive cardiac conduction defect · score 0.06
- Wolff-Parkinson-White Syndrome · score 0.05
- dilated cardiomyopathy · score 0.05
- familial sick sinus syndrome · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N966-F1 | alphafold | PREDICTED | 87.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N966.
Amino-acid sequence (263 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZDHHC22?
The strongest Open Targets associations for ZDHHC22 are Romano-Ward syndrome, smoking behavior, familial atrial fibrillation, Familial short QT syndrome and Brugada syndrome.
How long is the ZDHHC22 protein?
The Homo sapiens ZDHHC22 protein (UniProt Q8N966) is 263 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N966 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N966 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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