Leucine-rich repeat and transmembrane domain-containing protein 2 (LRTM2)
Homo sapiens — UniProt Q8N967
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and transmembrane domain-containing protein 2 (LRTM2) is a protein from Homo sapiens identified by UniProt accession Q8N967, 370 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q8N967; gene symbol LRTM2.
- Organism: Homo sapiens.
- Length: 370 amino acids.
- Top disease associations (Open Targets): mathematical ability, self reported educational attainment and central nervous system cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and transmembrane domain-containing protein 2 |
|---|---|
| UniProt accession | Q8N967 |
| Gene | LRTM2 |
| Organism | Homo sapiens |
| Length | 370 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.18
- self reported educational attainment · score 0.17
- central nervous system cancer · score 0.04
- lymphocyte count · score 0.03
- glioblastoma multiforme · score 0.03
- breast carcinoma · score 0.03
- Agents acting on the renin-angiotensin system use measurement · score 0.02
- septic shock · score 0.01
- neoplasm · score 0.01
- autism · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N967-F1 | alphafold | PREDICTED | 79.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N967.
Amino-acid sequence (370 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRTM2?
The strongest Open Targets associations for LRTM2 are mathematical ability, self reported educational attainment, central nervous system cancer, lymphocyte count and glioblastoma multiforme.
How long is the LRTM2 protein?
The Homo sapiens LRTM2 protein (UniProt Q8N967) is 370 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N967 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N967 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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