Zinc finger protein 557 (ZNF557)
Homo sapiens — UniProt Q8N988
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 557 (ZNF557) is a protein from Homo sapiens identified by UniProt accession Q8N988, 423 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q8N988; gene symbol ZNF557.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): refractive error measurement, appendicular lean mass and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 557 |
|---|---|
| UniProt accession | Q8N988 |
| Gene | ZNF557 |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.11
- appendicular lean mass · score 0.10
- lean body mass · score 0.10
- fat body mass · score 0.09
- body height · score 0.07
- whole body water mass · score 0.07
- Red cell distribution width · score 0.06
- BMI-adjusted waist-hip ratio · score 0.06
- BMI-adjusted waist circumference · score 0.05
- triglyceride measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N988-F1 | alphafold | PREDICTED | 74.79 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N988.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF557?
The strongest Open Targets associations for ZNF557 are refractive error measurement, appendicular lean mass, lean body mass, fat body mass and body height.
How long is the ZNF557 protein?
The Homo sapiens ZNF557 protein (UniProt Q8N988) is 423 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N988 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N988 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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