RNA ligase 1 (RLIG1)
Homo sapiens — UniProt Q8N999
Data last refreshed: (UniProt release unknown)
Key facts
RNA ligase 1 (RLIG1) is a protein from Homo sapiens identified by UniProt accession Q8N999, 325 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.
- UniProt accession: Q8N999; gene symbol RLIG1.
- Organism: Homo sapiens.
- Length: 325 amino acids.
- Top disease associations (Open Targets): Joubert syndrome, Meckel syndrome and nephronophthisis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RNA ligase 1 |
|---|---|
| UniProt accession | Q8N999 |
| Gene | RLIG1 |
| Organism | Homo sapiens |
| Length | 325 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (65)
Diseases linked to this target (Open Targets).
- Joubert syndrome · score 0.55
- Meckel syndrome · score 0.55
- nephronophthisis · score 0.55
- Bardet-Biedl syndrome 14 · score 0.54
- Joubert syndrome 5 · score 0.52
- Meckel syndrome, type 4 · score 0.52
- Leber congenital amaurosis 10 · score 0.51
- Senior-Loken syndrome 6 · score 0.50
- Leber congenital amaurosis · score 0.48
- genetic disorder · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N999-F1 | alphafold | PREDICTED | 92.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N999.
Amino-acid sequence (325 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RLIG1?
The strongest Open Targets associations for RLIG1 are Joubert syndrome, Meckel syndrome, nephronophthisis, Bardet-Biedl syndrome 14 and Joubert syndrome 5.
How long is the RLIG1 protein?
The Homo sapiens RLIG1 protein (UniProt Q8N999) is 325 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N999 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N999 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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