Protein FAM133A (FAM133A)
Homo sapiens — UniProt Q8N9E0
Data last refreshed: (UniProt release unknown)
Key facts
Protein FAM133A (FAM133A) is a protein from Homo sapiens identified by UniProt accession Q8N9E0, 248 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q8N9E0; gene symbol FAM133A.
- Organism: Homo sapiens.
- Length: 248 amino acids.
- Top disease associations (Open Targets): 3-hydroxy-1-methylpropylmercapturic acid measurement, blood coagulation disease and non-small cell lung carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein FAM133A |
|---|---|
| UniProt accession | Q8N9E0 |
| Gene | FAM133A |
| Organism | Homo sapiens |
| Length | 248 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.32
- blood coagulation disease · score 0.14
- non-small cell lung carcinoma · score 0.04
- hepatocellular carcinoma · score 0.03
- upper face morphology measurement · score 0.03
- neoplasm · score 0.01
- small cell lung carcinoma · score 0.01
- Tetralogy of Fallot · score 0.01
- colorectal cancer · score 0.00
- papillary thyroid carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9E0-F1 | alphafold | PREDICTED | 62.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9E0.
Amino-acid sequence (248 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAM133A?
The strongest Open Targets associations for FAM133A are 3-hydroxy-1-methylpropylmercapturic acid measurement, blood coagulation disease, non-small cell lung carcinoma, hepatocellular carcinoma and upper face morphology measurement.
How long is the FAM133A protein?
The Homo sapiens FAM133A protein (UniProt Q8N9E0) is 248 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9E0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9E0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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