N-acetylaspartate synthetase (NAT8L)
Homo sapiens — UniProt Q8N9F0
Data last refreshed: (UniProt release unknown)
Key facts
N-acetylaspartate synthetase (NAT8L) is a protein from Homo sapiens identified by UniProt accession Q8N9F0, 302 residues long. MolForge cross-references it against 0 known binders and 55 disease associations.
- UniProt accession: Q8N9F0; gene symbol NAT8L.
- Organism: Homo sapiens.
- Length: 302 amino acids.
- Top disease associations (Open Targets): N-acetylaspartate deficiency, Microcephaly and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | N-acetylaspartate synthetase |
|---|---|
| UniProt accession | Q8N9F0 |
| Gene | NAT8L |
| Organism | Homo sapiens |
| Length | 302 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (55)
Diseases linked to this target (Open Targets).
- N-acetylaspartate deficiency · score 0.45
- Microcephaly · score 0.11
- hepatocellular carcinoma · score 0.07
- Monoamine oxidase A deficiency · score 0.06
- Asperger syndrome · score 0.04
- childhood disintegrative disorder · score 0.04
- 15q11q13 microduplication syndrome · score 0.03
- body height · score 0.03
- breast carcinoma · score 0.03
- systolic blood pressure · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9F0-F1 | alphafold | PREDICTED | 79.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9F0.
Amino-acid sequence (302 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NAT8L?
The strongest Open Targets associations for NAT8L are N-acetylaspartate deficiency, Microcephaly, hepatocellular carcinoma, Monoamine oxidase A deficiency and Asperger syndrome.
How long is the NAT8L protein?
The Homo sapiens NAT8L protein (UniProt Q8N9F0) is 302 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9F0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9F0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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