Zinc finger protein 454 (ZNF454)
Homo sapiens — UniProt Q8N9F8
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 454 (ZNF454) is a protein from Homo sapiens identified by UniProt accession Q8N9F8, 522 residues long. MolForge cross-references it against 0 known binders and 12 disease associations.
- UniProt accession: Q8N9F8; gene symbol ZNF454.
- Organism: Homo sapiens.
- Length: 522 amino acids.
- Top disease associations (Open Targets): Abnormality of refraction, Down syndrome and refractive error.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 454 |
|---|---|
| UniProt accession | Q8N9F8 |
| Gene | ZNF454 |
| Organism | Homo sapiens |
| Length | 522 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (12)
Diseases linked to this target (Open Targets).
- Abnormality of refraction · score 0.04
- Down syndrome · score 0.04
- refractive error · score 0.03
- pancreatic adenocarcinoma · score 0.03
- Ataxia-telangiectasia · score 0.01
- lung adenocarcinoma · score 0.01
- neoplasm · score 0.01
- squamous cell lung carcinoma · score 0.01
- serous adenocarcinoma · score 0.01
- mitochondrial DNA depletion syndrome 4a · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9F8-F1 | alphafold | PREDICTED | 73.24 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9F8.
Amino-acid sequence (522 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF454?
The strongest Open Targets associations for ZNF454 are Abnormality of refraction, Down syndrome, refractive error, pancreatic adenocarcinoma and Ataxia-telangiectasia.
How long is the ZNF454 protein?
The Homo sapiens ZNF454 protein (UniProt Q8N9F8) is 522 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9F8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9F8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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