Exonuclease mut-7 homolog (EXD3)
Homo sapiens — UniProt Q8N9H8
Data last refreshed: (UniProt release unknown)
Key facts
Exonuclease mut-7 homolog (EXD3) is a protein from Homo sapiens identified by UniProt accession Q8N9H8, 876 residues long. MolForge cross-references it against 0 known binders and 29 disease associations.
- UniProt accession: Q8N9H8; gene symbol EXD3.
- Organism: Homo sapiens.
- Length: 876 amino acids.
- Top disease associations (Open Targets): chronotype measurement, mathematical ability and brain volume measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exonuclease mut-7 homolog |
|---|---|
| UniProt accession | Q8N9H8 |
| Gene | EXD3 |
| Organism | Homo sapiens |
| Length | 876 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (29)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.35
- mathematical ability · score 0.30
- brain volume measurement · score 0.30
- circadian rhythm · score 0.29
- insomnia measurement · score 0.29
- multisite chronic pain · score 0.29
- self reported educational attainment · score 0.27
- lean body mass · score 0.23
- unipolar depression · score 0.22
- cognitive function measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9H8-F1 | alphafold | PREDICTED | 78.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9H8.
Amino-acid sequence (876 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with EXD3?
The strongest Open Targets associations for EXD3 are chronotype measurement, mathematical ability, brain volume measurement, circadian rhythm and insomnia measurement.
How long is the EXD3 protein?
The Homo sapiens EXD3 protein (UniProt Q8N9H8) is 876 amino acids long.
Browse: Targets: E · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9H8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9H8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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