Synaptotagmin-2 (SYT2)
Homo sapiens — UniProt Q8N9I0
Data last refreshed: (UniProt release unknown)
Key facts
Synaptotagmin-2 (SYT2) is a protein from Homo sapiens identified by UniProt accession Q8N9I0, 419 residues long. MolForge cross-references it against 0 known binders and 232 disease associations.
- UniProt accession: Q8N9I0; gene symbol SYT2.
- Organism: Homo sapiens.
- Length: 419 amino acids.
- Top disease associations (Open Targets): Congenital myasthenic syndromes, myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive and botulism.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptotagmin-2 |
|---|---|
| UniProt accession | Q8N9I0 |
| Gene | SYT2 |
| Organism | Homo sapiens |
| Length | 419 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (232)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.72
- myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive · score 0.58
- botulism · score 0.50
- Presynaptic congenital myasthenic syndromes · score 0.37
- cortical thickness · score 0.30
- cortical surface area measurement · score 0.28
- Muscle weakness · score 0.26
- Respiratory distress · score 0.26
- glioblastoma multiforme · score 0.23
- neurodegenerative disease · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9I0-F1 | alphafold | PREDICTED | 80.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9I0.
Amino-acid sequence (419 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SYT2?
The strongest Open Targets associations for SYT2 are Congenital myasthenic syndromes, myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive, botulism, Presynaptic congenital myasthenic syndromes and cortical thickness.
How long is the SYT2 protein?
The Homo sapiens SYT2 protein (UniProt Q8N9I0) is 419 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9I0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9I0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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