E3 ubiquitin-protein ligase DTX3 (DTX3)
Homo sapiens — UniProt Q8N9I9
Data last refreshed: (UniProt release unknown)
Key facts
E3 ubiquitin-protein ligase DTX3 (DTX3) is a protein from Homo sapiens identified by UniProt accession Q8N9I9, 347 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q8N9I9; gene symbol DTX3.
- Organism: Homo sapiens.
- Length: 347 amino acids.
- Top disease associations (Open Targets): calcium measurement, Blackfan-Diamond anemia and lymphocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | E3 ubiquitin-protein ligase DTX3 |
|---|---|
| UniProt accession | Q8N9I9 |
| Gene | DTX3 |
| Organism | Homo sapiens |
| Length | 347 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- calcium measurement · score 0.11
- Blackfan-Diamond anemia · score 0.08
- lymphocyte count · score 0.08
- hereditary persistence of fetal hemoglobin-sickle cell disease syndrome · score 0.08
- papillary thyroid carcinoma · score 0.07
- smoking initiation · score 0.07
- blood protein measurement · score 0.07
- alpha thalassemia-intellectual disability syndrome type 1 · score 0.07
- Alpha-thalassemia - intellectual disability syndrome linked to chromosome 16 · score 0.07
- vertebral disorder · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9I9-F1 | alphafold | PREDICTED | 82.43 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9I9.
Amino-acid sequence (347 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DTX3?
The strongest Open Targets associations for DTX3 are calcium measurement, Blackfan-Diamond anemia, lymphocyte count, hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and papillary thyroid carcinoma.
How long is the DTX3 protein?
The Homo sapiens DTX3 protein (UniProt Q8N9I9) is 347 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9I9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9I9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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