Zinc finger protein ZIC 4 (ZIC4)
Homo sapiens — UniProt Q8N9L1
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein ZIC 4 (ZIC4) is a protein from Homo sapiens identified by UniProt accession Q8N9L1, 334 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.
- UniProt accession: Q8N9L1; gene symbol ZIC4.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): cortical surface area measurement, brain volume measurement and brain measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein ZIC 4 |
|---|---|
| UniProt accession | Q8N9L1 |
| Gene | ZIC4 |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (158)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.41
- brain volume measurement · score 0.40
- brain measurement · score 0.37
- body height · score 0.35
- smoking status measurement · score 0.34
- risky sexual behaviour measurement · score 0.33
- diet measurement · score 0.33
- neuroimaging measurement · score 0.32
- vital capacity · score 0.30
- cortical thickness · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9L1-F1 | alphafold | PREDICTED | 62.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9L1.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZIC4?
The strongest Open Targets associations for ZIC4 are cortical surface area measurement, brain volume measurement, brain measurement, body height and smoking status measurement.
How long is the ZIC4 protein?
The Homo sapiens ZIC4 protein (UniProt Q8N9L1) is 334 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9L1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9L1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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