Peroxisomal succinyl-coenzyme A thioesterase (ACOT4)
Homo sapiens — UniProt Q8N9L9
Data last refreshed: (UniProt release unknown)
Key facts
Peroxisomal succinyl-coenzyme A thioesterase (ACOT4) is a protein from Homo sapiens identified by UniProt accession Q8N9L9, 421 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.
- UniProt accession: Q8N9L9; gene symbol ACOT4.
- Organism: Homo sapiens.
- Length: 421 amino acids.
- Top disease associations (Open Targets): urinary metabolite measurement, creatinine measurement and Intellectual disability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peroxisomal succinyl-coenzyme A thioesterase |
|---|---|
| UniProt accession | Q8N9L9 |
| Gene | ACOT4 |
| Organism | Homo sapiens |
| Length | 421 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (36)
Diseases linked to this target (Open Targets).
- urinary metabolite measurement · score 0.27
- creatinine measurement · score 0.20
- Intellectual disability · score 0.15
- phosphatidylcholine measurement · score 0.05
- leukocyte count · score 0.04
- glomerular filtration rate · score 0.03
- acute myeloid leukemia · score 0.03
- blood metabolite measurement · score 0.03
- systolic blood pressure · score 0.02
- reticulocyte count · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q8N9L9-F1 | alphafold | PREDICTED | 96.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q8N9L9.
Amino-acid sequence (421 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ACOT4?
The strongest Open Targets associations for ACOT4 are urinary metabolite measurement, creatinine measurement, Intellectual disability, phosphatidylcholine measurement and leukocyte count.
How long is the ACOT4 protein?
The Homo sapiens ACOT4 protein (UniProt Q8N9L9) is 421 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q8N9L9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q8N9L9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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